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The compound forms critical hydrogen bonds at the bottom of these binding pockets, interacting with specific receptor residues that facilitate its action

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The effect is dose-dependent and reversible (after discontinuation, pigmentation subsides over weeks to months)

These individuals may experience abrupt elevations in alanine aminotransferase (ALT) levels exceeding 1,000 U/L within 14 months of use, often accompanied by autoimmune hepatitis-like features