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GLP-1RAs, glucagon-like peptide-1 receptor agonists

On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

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Li P, Zhu L, Yang X, Li W, Sun X, Yi B, et al

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Drugs like semaglutide and tirzepatide have shown significant benefits for both type 2 diabetes and obesity