N Engl J Med 389(12):10691084 Kosiborod MN, Petrie MC, Borlaug BA, Javed B, Davies MJ, Hovingh GK et al (2024) Semaglutide in patients with obesity-related heart failure and type 2 diabetes
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The most common were gastrointestinal-related, including nausea, constipation and diarrhea
GPR41, G Protein-Coupled Receptor 41
Common targets include glutamate/NMDAR overactivity, undermethylation, copper-zinc imbalance, histamine, pyroluria, oxidative stress, toxic burden, and gut inflammation
Fortunately, this is usually mild and goes away within a few hours or days