It is also possible that some of the effects of GLP-1 agonists on food intake may be mediated by interaction with sensory afferent neurones of the vagus nerves in the gastrointestinal tract
Recent concerns have emerged regarding a potential link between GLP-1 agonists and suicidal ideation, prompting regulatory reviews by the MHRA and EMA
In clinical trials, GLP-1RAs were well tolerated and effective at helping people prevent weight regain, and may be a good option for long-term weight control and lowering patients chances of serious health problems
A total of 12,519 patients met the inclusion criteria for the primary dose analysis, and their clinical data on dose escalation and weight change during the first two years after semaglutide initiation were assessed in relation to cardiovascular outcomes during the subsequent two years
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Cervera A, Wajcberg E, Sriwijitkamol A, et al