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Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 18(10), 22262233.e4

This prolonged activity maintains appetite reduction throughout the entire dosing interval, preventing fluctuations in hunger signals

Retatrutide CAS: Ref

If the same step fails twice, that dose level may be your minimum effective dose, and continuing the taper may not be appropriate

1 2 3 4 5 "Rybelsus EPAR"

Tirzepatide may lead to more pronounced gastrointestinal problems due to its dual action, while Retatrutides side effects seem slightly milder based on initial studies