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Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation, because of the link between GLP-1 release and nausea, and the link between PYY release and postprandial fullness ( In summary, there is a clear need for in-depth evaluation of release of GI peptides after a standard meal in larger sample sizes of Rome IV PDS and EPS and gastroparesis patients

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This recommendation was developed following 6 cases of non-fatal aspiration in fasted patients taking GLP-1 RAs, and is aimed at reducing the risk of the much-feared pulmonary aspiration seen in unfasted patients with an unprotected airway

doi:10.1589/jpts.34.503

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