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TYK2 inhibition in human cells prevented IFN-induced ER stress, cytokine-mediated apoptosis, and upregulation of HLA class I molecules and CXCL10, thereby limiting pathological interactions between cells and T cells (123)

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Liver tissue was crushed and prepared with previously described methods to separate the aqueous, lipid, and protein layers, 9 and sent to the Department of Biochemistry at the University of Cambridge, Cambridge, UK, where liquid chromatography mass spectrometry was undertaken

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