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The prevalence of vitamin B12 deficiency is particularly elevated among patients with T2D, with studies demonstrating that up to 64% of those with DPN exhibit altered (low or borderline) vitamin B12 levels compared with only 17% of patients without neuropathy

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Although, like carnitine, CLA may cause minor side effects, such as abdominal discomfort, constipation, and diarrhea

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In subchondral bone, chronic mechanical stress leads to microfracture, osteosclerosis, and angiogenesis, often accompanied by excessive iron deposition and oxidative stress

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Radiology 168 , 203206 (1988)

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