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There is also a confidence loop

Around 60% of the variance in the neuropsychiatric symptoms of Long COVID (a factor extracted from HAMD, HAMA and FF scores) was explained by OSTOX/ANTIOX ratio, PBT and SpO2

At this scale, the surface-to-volume ratio is high, and it provides large surface area for interactions with the biological molecules leading to higher sensitivity, and enhanced specificity with reduced time for reaction [336]

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In contrast, increased frontal activation and/or normalization of abnormal connectivity have been associated with improvement of pain and of sad mood (Li et al., 2018