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The result, after nearly two decades of development, was exenatide (Byetta) , which received FDA approval in April 2005 as the first GLP-1 receptor agonist approved for clinical use

New approaches are offering hope where traditional methods max out

The thigh offers a large, easily accessible injection site for semaglutide therapy, with subcutaneous administration into the quadriceps or outer thigh allowing consistent medication delivery

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A 2022 study found that participants regained twothirds of their weight loss within the first year after stopping their GLP1 usage

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