Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines
Caution should be taken when erythromycin is co-administered with agents that alter or are metabolized by cytochrome P450 (CYP) 3A4 (e.g., diltiazem or verapamil or domperidone) because the drug interactions may be associated with risk for sudden cardiac death (Ray et al., 2004)
"If you have a history of diverticulitis and you develop mild symptoms, let your doctor know
If you want to hide personal information on the label, use a permanent marker to cover it before disposal.
Further research is necessary to ascertain whether differences among DPP4 inhibitors might influence the occurrence of specific adverse effects
The simplest way to think about them is in two buckets: stomach symptoms during dose escalation, and a separate skin-sensation signal at the highest dose in Phase 3