Establishing a long-term prospective registry study has been suggested in a recent Endocrine Society Scientific Statement on this topic (Pope et al., 2014) and this could prove very valuable in determining the long-term safety of PEDs

Ingredients: Water, Centella Asiatica Extract (22.7%), Glycerin, Cetyl Ethylhexanoate, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Niacinamide (20,000ppm), Stearic Acid, Sodium Polyacryloyldimethyl Taurate, Silica, Sodium Hyaluronate, Glyceryl Stearate, Beeswax, Butyrospermum Parkii (Shea) Macad amia Ternifolia Seed Oil, Hydrogenated Polydecene, Betaine, Glutathione (1,000ppm), Trehalose, Adenosine, Citric Acid, Trideceth-10, Disodium Edta, Sodium Citrate, Caprylic/capric Triglyceride, Hydrogenated Lecithin, Cholesterol, Xanthan Gum, Nelumbo Nucifera Extract, Artemisia Annua Extract, Oryza Sativa (Rice) Extract, Saccharomyces Ferment, Solanum Melongena (Eggplant) Fruit Extract, Melaleuca Alternifolia (Tea Tree) Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-glucan, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Madecassic Acid, Asiaticoside, Asiatic Acid, Propanediol, Hydroxyacetophenone, 1,2-hexanediol, Ethylhexylglycer in, Dipotassium Glycyrrhizate

By neutralizing oxidative stress glutathione helps maintain skin elasticity, reduce hyperpigmentation, lighten melasma, and support a more even, luminous complexion over time
Research indicates that glutathione levels are closely linked to the development and progression of various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)
1Azorubine: may have an adverse effect on activity and attention in children
Insulin receptor is a tyrosine kinase receptor with two extracellular subunits and two transmembrane subunits (Ye et al., 2017)