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This fullness can increase the likelihood of stomach contents, including acid, flowing back into the esophagus, especially if the lower esophageal sphincter (the muscle that acts as a valve between the stomach and esophagus) is weakened or relaxed

Comparison of the cited figures, however, does provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the side-effect incidence rate in the population studied

Still clinically insignificant, but the percentage error is larger

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