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Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies
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The brand-name medication is approved by the U.S
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Semaglutide and tirzepatide both reduce appetite and slow gastric emptying, but they differ in dosing, clinical weight loss averages, and side effect profiles