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Active infections and uncontrolled chronic conditions should not be present in the patients

Following multiple regression analysis, a changing pattern in IL-1 was found, and the Charlson Comorbidity Index was separately associated with changes in S100

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This condition leads to a wide range of complications that significantly affect various organs and systems [171]

The interplay between these regulators creates a dynamic checkpoint: mTORC1 and HIF-1 synergize to propel effector T cell responses under nutrient-rich conditions, whereas AMPK activation restrains anabolic metabolism to favor regulatory phenotypes during energy stress

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