ckd glp-1 Glucagon-Like Peptide-1 Receptor Agonist Use in People Living with Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Narrative Review of the Key Evidence with Practical Considerations | Diabetes Therapy Updates in Medicine | CKD

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Expanding the use of GLP-1 receptor agonists across obesity, cardiovascular disease, chronic kidney disease, MASH, and other metabolic disorders requires manufacturers to generate robust long-term clinical evidence for each therapeutic indication

Another GLP1 derived peptide has been described that features OGlcNAc glycosylation of ser18, as well as 2aminoisobutyric acid substitutions at positions 2 and 16, is biased in favour of cAMP signalling over arrestin recruitment (Levine et al., 2019)

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