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The field should adopt more rigorous standards, including the use of selective inhibitors and genetic tools to validate proposed hubs, and employ advanced ex vivo models like patient-derived cells or organoids to better assess the therapeutic relevance of these dual-targeting approaches before considering clinical translation

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Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT (2015) Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

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Unfortunately, the internet is flooded with low-grade, poorly synthesized compounds pushed by vendors who care more about profit margins than human biochemistry