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Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, et al

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The resulting elimination half-life of approximately 6 days supports convenient once-weekly subcutaneous dosing

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