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GLP-1 RAs are avoided primarily due to a lack of sufficient human safety data

Efficacy of GLP-1 RAs in Weight Loss GLP-1 RAs have consistently demonstrated effectiveness for weight loss in clinical trials among individuals with obesity compared with placebo treatments 17,18

They make you feel satisfied on less food

Glucose is the only source of energy in the brain because the brain cannot use fat or protein as alternative energy sources

After the landmark SPRINT trial, published in 2015, found that lower blood pressure significantly reduced the risk of cardiovascular outcomes and death, the threshold for high blood pressure (hypertension) was lowered from 140/90 mm Hg to 130/80 mm Hg

Valles-Colomer M, Menni C, Berry SE, Valdes AM, Spector TD, Segata N