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Exercise and cold exposure induce PGC-1 coactivators, amplifying ERR-dependent gene sets involved in fatty-acid uptake and -oxidation (for example, CPT1, MCAD), OXPHOS subunits, TCA cycle enzymes, and mitochondrial transcription factors (for example, TFAM)
It is specifically noted as a useful adjunct for poisoned patients who are presenting with isolated pulmonary symptoms (Charejoo et al, 2023)