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It is known that mTORC2 phosphorylates Akt and appears to regulate mainly cell proliferation and cell survival [110] (Figure 4) The effect growth factors have on mTORC1 is mediated through phosphatidylinositol-3,4,5-triphosphate kinase (PI3K) activation, the subsequent activation of phosphoinositide-dependent kinase (PDK1) and Akt

Meanwhile, that will promote the production of excessive reactive oxygen species (ROS), change the balance of oxidation and reduction in cells and will lead to oxidative stress ( In order to prevent oxidative damage caused by adverse conditions, aquaculture animals must have an effective antioxidant system, such as endogenous free radical scavenging enzymes and exogenous antioxidants ( 2 O 2 ) in the body tissues ( At present, the research on Se antioxidant stress has involved inorganic Se (such as sodium selenite), organic Se (such as yeast Se, selenomethionines) and nano Se

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Mandal A, Drerup CM

Metabolic and genomic response to dietary isocaloric protein restriction in the rat