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LOX mainly comprises of five members that were originally considered copper-dependent amine oxidases, including lysyl oxidase and lysyl oxidase-like 1-4 (LOXL1-LOXL4), is a copper-containing amine oxidase belonging to a heterogeneous family of enzymes, which catalyzes oxidative deamination of the amino group in certain lysine and hydroxylysine residues of collagen molecules for stabilization of collagen fibrils (Kagan and Li, 2003)

A negative association with fertility was also supported by the NHS-II study (115)