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People who notice progressive hollowing of the mid-face, reduced definition along the jawline, or generalized skin laxity that isnt responding to topical interventions tend to see better outcomes with GH-releasing peptides like Tesamorelin than with surface-level aesthetics alone

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Sharabi A, Cohen E, Sulkes J, et al

From 2004 to 2009, an analysis of the database revealed a six-fold increase in pancreatitis incidents linked to the DPP-4 inhibitor sitagliptin and the GLP-1 mimetic exenatide, the first two GLP-1-based medications marketed in the US [51]