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The underlying mechanisms have not been fully delineated but are likely to involve modulation of the brain dopamine reward system via GLP-1 receptors, which are present both in the ventral tegmental areas (VTA), where dopamine neurons are located, and in the nucleus accumbens (NAc), which is the main projection of VTA dopamine neurons 14

However, the precise role of 15LO1 and its products in disease pathogenesis remains enigmatic

These hypotheses will need to be explored in a randomized study

Wagh, Sandip University, India Reviewed by Lingru Li, Beijing University of Chinese Medicine, China Hou Wen, Gannan Medical University, China Jun Zhou, Shandong First Medical University, China Updates Copyright 2024 Rao, Qiu, Zhang and Wang

The molecular systems involved include actin cytoskeletal remodeling and integrin signaling, with focal adhesion pathways facilitating attachment of fibroblasts to collagen