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Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to Metformin in subjects with type 2 diabetes

No comparable human data exist

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Neurotoxicology 42 (2014): 49-57

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Its limits are specific: it gives little weight to cumulative burden in younger people, and it can understate risk in those whose LDL-C looks reassuring but whose particle number does not