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Quick Answer: Tirzepatide may reduce inflammatory markers like high-sensitivity C-reactive protein, though it is unclear whether this represents direct anti-inflammatory effects or secondary benefits from weight loss and improved glycemic control

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Administration of linagliptin (10 mg/kg/day), a DPP-4 inhibitor, to ApoE / mice, an animal model of atherosclerosis, decreased inflammatory molecule expression and macrophage infiltration in the atherosclerotic aorta [65]