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The MHRA approved tirzepatide following clinical trials demonstrating superior glycaemic control and weight loss compared to other GLP-1 receptor agonists

Some compounding pharmacies are making copycat versions of the diabetes drug Ozempic and the weight-loss drug Wegovy, and people are reporting unwanted side effects from these unauthorized medications, the Food and Drug Administration (FDA) warned this week

In addition to standing up to DPP-4s breakdown action better than analogous human hormones, some of the first-generation GLP-1 drugs, like exenatide, have also been shown to cross the blood-brain barrier in rodents

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It also notes that as GLP-1 therapy drives weight loss, thyroid hormone requirements may change, and that any change should follow TSH trends rather than weight alone