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Elevated cortisol directly inhibits GH receptor signaling in target tissues and increases hepatic GH resistance, meaning even if you achieve a GH pulse, downstream IGF-1 production and metabolic signaling are impaired
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The concern behind this limited approval is that this vaccine predisposed some of the dengue-nave recipients to severe dengue fever due to their cross-reactivity with other DENV serotypes, thereby contributing to ADE
Neuroprotection: Protects against ischemic stroke and CNS damage via the gutbrain axis (PMC8504390)
