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The persistent presence of pathogens, such as viruses or bacteria, or their residual components (e.g., the spike protein of SARS-CoV-2), may function as pathogen-associated molecular patterns (PAMPs), continuously activating pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), thereby providing a potential foundational pro-inflammatory signal (122)

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Although gradients of Percoll became popular in the early nineteen-eighties for the enrichment of motile spermatozoa from human semen, several groups of workers recognized that the use of an iodinated density gradient medium that was already approved for human injection as an X-ray contrast agent offered a much more attractive solution for this procedure

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Di Tucci, C., Galati, G., Mattei, G., Bonanni, V., Capri, O., D'Amelio, R., Muzii, L., & Benedetti Panici, P

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