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However, in atretic follicles, FSH may activate autophagy via different signaling pathways, leading to granulosa cells degradation and triggering follicular atresia ( Overall, the role of autophagy in establishing the follicular pool and promoting follicular survival highlights its potential as a novel therapeutic target for addressing DOR in vulnerable populations, such as those exposed to chemotherapy, environmental toxins, or genetic disorders (Figure 3B)

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These technology-driven developments are especially important in managing chronic conditions over long durations

Upon inhibition of wild-type p53 in these cells, they surprisingly responded with a drastic IGF-1R downregulation and cell death (Girnita et al, 2000)

Suleiman Al-Sabah, Kuwait University, Kuwait

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