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The basics: Apply patches to clean, dry skin in the morning Wear for a maximum of 12 hours, then remove and discard Do not reuse a patch once it has been removed the crystals have already done their work Rotate placement locations to avoid skin sensitivity Stay well hydrated this matters more than most people realize when using phototherapy Why only 12 hours

Hence it stands to reason that there must be evidence of such stress pre-recruitment, or its confident expectation on the basis of numerous published reports - provided that ineligible patients are excluded and that patients do not change their lifestyles for the duration of a trial

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doi: 10.3389/fonc.2025.1568391 Received 06 February 2025 Accepted 23 May 2025 Published 09 June 2025 Corrected 17 July 2025 Volume 15 - 2025 Edited by Jianqiang Xu, Dalian University of Technology, China Reviewed by Sivapar V