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HGF mostly exerts an anti-fibrotic effect on glial scar reduction by inhibiting the synthesis of the proteoglycans produced by the activated astrocytes through the complete block of TGF-1 and TGF-2 action

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To generate CM-10-D1 (Leu-Ile-Ala-Asn-Aib-Lys), the alanine in CM-10 was substituted with the unnatural amino acid aminoisobutyric acid to increase peptide stability