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For example, metabolic inhibitors such as metformin and doxycycline, which target OXPHOS and mitochondrial biogenesis, respectively, have demonstrated variable efficacy against CSCs
According to the Mayo Clinic, most people consume adequate amounts of B vitamins through their diet, though the elderly, particularly those with pernicious anemia, athletes, strict vegetarians, and people who consume a lot of alcohol may be deficient in the B vitamins and may require injections or oral supplementation of B vitamins or vitamin B-12, in particular