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When acetylcarnitine is injected directly into the brain, most of the acetyl groups were metabolized, as 60% of the injected acetylcarnitine was recovered as exhaled 14 CO 2 after 22 h, and the percentage recovered in the brain was 1.9, 1.6, 1.3, and 0.9% at 1, 3, 6, and 22 h, respectively [109]

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Furthermore, these increased levels of pro-inflammatory cytokines resulted in an increase of corticotropin-releasing hormone activity and hyperactivity of the HPA axis in most patients with depression (Kopschina Feltes et al., 2017)