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Simultaneously, it could increase vascular leak in sensitive tissues (Thorin et al., 2023

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In the trials, the most common were: Nausea Diarrhea Constipation Vomiting These effects were usually mild to moderate and tended to show up early in the first few weeks of treatment or right after a dose increase

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doi: 10.1002/advs.202505359 251 SuWGaoYJiaXChenXWuJWenYet al

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In contrast, in PARP / mice, normal blood glucose and islet structure have been observed, indicating that the deletion of PARP can completely protect STZ-induced diabetes ( Conventional therapies, including anti-diabetic drug therapy, only slow down the onset of TD2M progression and do not remotely heal the disease

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