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An area of growing interest involves the ability to not only enter the CNS but target specific immune cell types

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CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1

doi: 10.1111/bcp.14855 34 YangWSLeeWJFunahashiTTanakaSMatsuzawaYChaoCLet al

Gut 61: 632, 2012

( 65 is selectively associated with GABAergic nerve endings and therefore plays an important regulatory role in synthesis of neurotransmitter GABA ( 65 knock-out (GAD 65 / ) animals are susceptible to induced seizures ( 67 is found throughout the cytosol of these neurons and therefore may serve as the biosynthetic enzyme for the GABA pool associated with metabolism [i.e., consistent with a housekeeping function