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It is known that the Angiotensin IV/AT4 system: has cerebroprotective effects, augments long term potentiation, has well established pro-cognitive effects, and is suspected to regulate neural stem cell development

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Peptides alter cellular growth pathways

The NAPstar3b variant was generated by site-directed mutagenesis on the pDONR207 NAPstar3 plasmid using the primer pair Pr1/Pr2 ( Supplementary Table 6 )

Furthermore, transforming growth factor- 1 (TGF1), released by macrophages, modulates the expression of SLC7A11 via the Smad pathway

Other PTMs of NRF2 In addition to the above-mentioned PTMs, NRF2 undergoes a variety of other PTMs that also play important roles in regulating its stability, activity, and cellular localization