This is relevant for pregnant women, who are advised by the NHS to limit total caffeine intake to under 200 mg per day from all sources
The milligram dose depends entirely on concentration
In this context, it is essential to carefully weigh the individual course and symptom profile in order to make the optimal therapeutic decision
The need for caution in interpreting FAERS signals is acknowledged in FAERS analyses themselves
It identified legitimate methodological concerns (assay heterogeneity in the pharmacology comparison, Weber effect as a confounder in the FAERS analysis, uncertainty bounds on the efficacy extrapolation) and recommended specific textual revisions
Because poison center reports are voluntary and influenced by prescribing trends, media attention, and healthcare-seeking behavior, the findings cannot determine the true incidence of GLP-1 RA toxicity or establish causality