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In doing so, recent studies have demonstrated that alpha-cell-derived proglucagon peptides contribute to beta-cell glucose-stimulated insulin secretion (GSIS) (49), suggesting that alpha-cell regulation of glucose homeostasis and beta-function is more complex than previously appreciated

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In the present case, epiploic appendagitis occurred in temporal association with substantial and relatively rapid weight loss during tirzepatide dose escalation, consistent with the hypothesis that physiologic changes accompanying weight reduction may have influenced susceptibility, although causality cannot be inferred

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