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The reduced thiol group on the cysteine residue directly scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), becoming oxidized to GSSG in the process

BMC Nephrol 2024;25:130

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Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

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