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Until such data accrue, melatonin is a reasonable, low-risk adjunct to consider in PCOS-related infertility, particularly for patients prioritizing oocyte quality, while counseling that hard reproductive endpoints are not yet definitively established

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However, these data are in conflict with a previous report that demonstrated an enhanced mitochondrial function in the liver, muscle, heart, kidneys, and brain of aged GHRKO mice ( in vivo (Riedel et al., 2020)

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