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Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: Implications for Parkinsons disease

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I first became interested in amino acids when I learned about the role of the amino acid tyrosine, which is one of the raw materials required to make thyroid hormones, as well as glutamine, an amino acid that aids in repairing the gut

Bioconjugate Chem 25:611617 Chari RVJ (2008) Targeted cancer therapy: conferring specificity to cytotoxic drugs

Glutathione depletion impacts the gamma glutamyl cycle in the liver by increasing the activity of -glutamyl cysteine synthetase and accumulation of -glutamyl cysteine, which is converted by -glutamyl cyclotransferase to pyroglutamic acid/5-oxyproline [3, 4] (Fig