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However, increasing oral supplement doses (within safe limits) while awaiting medical review is generally considered safe, as B12 has very low toxicity and excess is excreted through the kidneys

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PEM is characterised by a delayed onset, prolonged duration, and an intensity disproportionate to the precipitating exertion (15, 16)

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Haemoglobin levels begin to rise after about one week, whilst the mean corpuscular volume (MCV), which is typically elevated in B12 deficiency, gradually normalises

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