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Pod wzgldem chemicznym Melanotan II jest peptydem cyklicznym o sekwencji aminokwasowej Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH , ktrej struktura bya przedmiotem licznych analiz w publikacjach naukowych z lat 90

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International journal of biological sciences 8 , 310327 (2012)