Safety and side effects: A meta-analysis of multiple studies in COPD patients showed no significant adverse effects at doses ranging from 600 mg to 3g/day.[ref] Studies in healthy adult athletes go up to 20g/day (not recommending this, just including it for safety).[ref] Conversely, in Parkinsons patients, there was a high number of adverse events at 6g/day of NAC
This is a more complicated question than it seems because obesity is so closely associated with increased cancer risk
During the Piper Sandler conference, Gorevic declined to "get out his crystal ball" to predict how many members will be on GLP-1s in 2024
The main advantage of Lurcher mice would be the expected absence of significant neuropathologies outside the olivocerebellar system that modify the complex behavioral phenotype in less selective models
GLP-1 producing preproglucagon-expressing neurons (PPG is cleaved into GLP-1) are located almost exclusively in NTS and project to CNS nuclei relevant for energy balance [43, 44]
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