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Off-label use means a medicine is prescribed outside its main licensed indication, based on clinical judgement

For example, in both neurodegenerative diseases like Alzheimer's and Parkinson's, the presence of fewer bacteria generating SCFA and the increased density of proinflammatory microbes lead to neuroinflammation and cognitive decline

These phytochemicals include polysaccharides as well as hericenones and erinacines

GLP-1R belongs to the class B family of G-protein-coupled receptors (GPCRs), which utilize a distinct peptide-binding mechanism compared to small-molecule GPCRs