However, the natural form of GLP-1 is quickly broken down in the body by an enzyme called dipeptidyl peptidase-4 (DPP-4)
The final fill/finish stage, when the drug is prepared and packaged for patients, also remains a major bottleneck
But, if youre looking for a cost-effective and easy-to-use option, semaglutide cant be beat
The prolonged half-life of GLP-1 analogs is achieved through several mechanisms, such as delayed absorption from the subcutaneous injection site, albumin binding, which shields the molecule from enzymatic degradation by DPP-4, and reduced renal clearance
doi: 10.1038/s41591-024-02996-7
For comparison, 70% of ACA Marketplace plans use at least 1 utilization management strategy with Xarelto (covered on 97% of formularies), a similarly priced oral anticoagulant with no generic formulation available