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Leiss H, Niederreiter B, Bandur T et al (2013) Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation

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These individuals are at an increased risk from environmental factors, including microbes and food components, interacting with the subepithelial immune system and entering systemic circulation to promote chronic inflammation and tissue damage in multiple extraintestinal sites