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In preclinical models of PDAC, while ablation of the tumour-restrictive -SMA + CAFs reduced survival, depletion of FAP + CAFs significantly improved survival and enhanced the efficacy of immune checkpoint inhibitors (ICIs) [243]

The administration of whey proteins restored the urea level, which had been decreased as a result of MTX administration and also reduced the increased creatinine level

2 show that inhibition of glutathione synthesis by BSO causes the lasting glutathione decrease strating from 24 h of culture

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Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA, et al