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However, excessive -adrenergic stimulation may induce cholestasis by increasing intrahepatic vascular resistance and impairing biliary excretion 31

Catalpol attenuates osteoporosis in ovariectomized rats through promoting osteoclast apoptosis via the Sirt6-ER-FasL axis

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Baseline covariates used were: age, sex, prior cardiovascular event, prior heart failure, diabetes duration, HbA 1c , estimated glomerular filtration rate (eGFR), weight, body mass index (BMI), diastolic blood pressure, systolic blood pressure, heart rate, low-density lipoprotein (LDL) cholesterol, insulin use, thiazolidinedione use, sulfonylurea use, angiotensin-converting-enzyme inhibitor (ACEi) use, angiotensin II receptor blocker use and statin use

GPx activity was measured using a kinetic colorimetric assay that measured activity indirectly by a coupled reaction with GR

In colon cancer cells (HT-29 and SW480 cells), genetic knockout of IGF-1R or the use of the IGF-1R inhibitor NVP-ADW742 enhanced the killing effect of radiation on cancer cells, confirming that depletion of IGF-1R improves radiosensitivity to colon cancer therapy (145,146)